Computational complexity of isothermic DNA sequencing by hybridization
نویسندگان
چکیده
منابع مشابه
Computational complexity of isothermic DNA sequencing by hybridization
In the paper, the computational complexity of several variants of the problem of isothermic DNA sequencing by hybridization, is analyzed. The isothermic sequencing is a recent method, in which isothermic oligonucleotide libraries are used during the hybridization with an unknown DNA fragment. The variants of the isothermic DNA sequencing problem with errors in the hybridization data, negative o...
متن کاملTabu search method for DNA sequencing by hybridization with isothermic libraries1
In this work, a problem of DNA sequencing by hybridization (SBH) with isothermic libraries, is considered. The classical approach to SBH uses sets of oligonucleotides of equal lengths [1, 2, 8, 10, 6, 9, 7]. In isothermic SBH approach new sets of oligonucleotides are used. The library cosists of oligonucleotides with the same melting temperature but different lengths [3, 4]. Every nucleotide ad...
متن کاملTabu search algorithm for DNA sequencing by hybridization with isothermic libraries
In this paper, a problem of isothermic DNA sequencing by hybridization (SBH) is considered. In isothermic SBH a new type of oligonucleotide libraries is used. The library consists of oligonucleotides of different lengths depending on an oligonucleotide content. It is assumed that every oligonucleotide in such a library has an equal melting temperature. Each nucleotide adds its increment to the ...
متن کاملAn algorithm for isothermic DNA sequencing
In the paper, the problem of isothermic DNA sequencing by hybridization, without any errors in its input data, is presented and an exact polynomial-time algorithm solving the problem is described. The correctness of the algorithm is confirmed by an enumerative proof.
متن کاملReconstruction of DNA sequencing by hybridization
MOTIVATION It is widely recognized that the hybridization process is prone to errors and that the future of DNA sequencing by hybridization is predicated on the ability to successfully cope with such errors. However, the occurrence of hybridization errors results in the computational difficulty of the reconstruction of DNA sequencing by hybridization. The reconstruction problem of DNA sequencin...
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ژورنال
عنوان ژورنال: Discrete Applied Mathematics
سال: 2006
ISSN: 0166-218X
DOI: 10.1016/j.dam.2005.05.028